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SMILES: Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCS(=O)(=O)CC2)n1

InChI Key: InChIKey=QWKSTAGFIWXTEL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173046   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173046
PNG
(US9096579, 148)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C21H20ClN7O3S/c1-28-11-18(24-12-28)16-2-3-23-21(27-16)25-14-8-13-9-17(26-19(13)15(22)10-14)20(30)29-4-6-33(31,32)7-5-29/h2-3,8-12,26H,4-7H2,1H3,(H,23,25,27)
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Similars
US Patent
n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair