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SMILES: Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)C#N)n1

InChI Key: InChIKey=LFOVSQXKOSVNCI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173050   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173050
PNG
(US9096579, 152)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)C#N)n1
Show InChI InChI=1S/C23H21ClN8O/c1-31-12-20(27-13-31)18-2-5-26-23(30-18)28-16-8-15-9-19(29-21(15)17(24)10-16)22(33)32-6-3-14(11-25)4-7-32/h2,5,8-10,12-14,29H,3-4,6-7H2,1H3,(H,26,28,30)
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Similars
US Patent
n/an/a 5.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair