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SMILES: Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCC1CCOCC1

InChI Key: InChIKey=BIHVSKBXOHZILU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173052   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM173052
PNG
(US9096579, 154)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCC1CCOCC1
Show InChI InChI=1S/C24H27N7O2/c1-15-9-18(28-24-25-6-3-19(30-24)21-13-31(2)14-27-21)10-17-11-20(29-22(15)17)23(32)26-12-16-4-7-33-8-5-16/h3,6,9-11,13-14,16,29H,4-5,7-8,12H2,1-2H3,(H,26,32)(H,25,28,30)
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Similars
US Patent
n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair