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SMILES: Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NNC=O

InChI Key: InChIKey=RGYMRFZCQUFANP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173072 (US9096579, 174) Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NNC=O Show InChI InChI=1S/C19H18N8O2/c1-11-5-13(6-12-7-15(24-17(11)12)18(29)26-22-10-28)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,22,28)(H,26,29)(H,20,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM173072 (US9096579, 174) Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NNC=O Show InChI InChI=1S/C19H18N8O2/c1-11-5-13(6-12-7-15(24-17(11)12)18(29)26-22-10-28)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,22,28)(H,26,29)(H,20,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US9096579 (2015) BindingDB Entry DOI: 10.7270/Q2F76B9H
					More data for this Ligand-Target Pair