BDBM17328 (2S)-2-[(1-{[3-cyclohexyl-1-(1,3-thiazol-5-yl)propoxy]carbonyl}-5-(2-methylphenyl)-1,2,3,6-tetrahydropyridin-4-yl)formamido]-4-(methylsulfanyl)butanoic acid::methionine containing tetrahydropyridine, 14

SMILES: CSCC[C@H](NC(=O)C1=C(CN(CC1)C(=O)OC(CCC1CCCCC1)c1cncs1)c1ccccc1C)C(O)=O

InChI Key: InChIKey=BJWFIOSIGHDXLF-QBHOUYDASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM17328 ((2S)-2-[(1-{[3-cyclohexyl-1-(1,3-thiazol-5-yl)prop...) Show SMILES CSCC[C@H](NC(=O)C1=C(CN(CC1)C(=O)OC(CCC1CCCCC1)c1cncs1)c1ccccc1C)C(O)=O |r,t:8| Show InChI InChI=1S/C31H41N3O5S2/c1-21-8-6-7-11-23(21)25-19-34(16-14-24(25)29(35)33-26(30(36)37)15-17-40-2)31(38)39-27(28-18-32-20-41-28)13-12-22-9-4-3-5-10-22/h6-8,11,18,20,22,26-27H,3-5,9-10,12-17,19H2,1-2H3,(H,33,35)(H,36,37)/t26-,27?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.710	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 13: 1359-62 (2003) Article DOI: 10.1016/S0960-894X(03)00095-7 BindingDB Entry DOI: 10.7270/Q2QJ7FK9
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