BDBM173674 US9102591, 2,3-dichloro-N-((4,4-difluoro-1-(5-fluoropyridin-3-yl)cyclohexyl)methyl)benzamide::US9649308, 2,3-dichloro-N-((4,4-difluoro-1-(5-fluoropyridin-3-yl)cyclohexyl)methyl)benzamide

SMILES: Fc1cncc(c1)C1(CNC(=O)c2cccc(Cl)c2Cl)CCC(F)(F)CC1

InChI Key: InChIKey=PMNDTJDYUDZUFR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 173674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173674 (US9102591, 2,3-dichloro-N-((4,4-difluoro-1-(5-fluo...) Show SMILES Fc1cncc(c1)C1(CNC(=O)c2cccc(Cl)c2Cl)CCC(F)(F)CC1 Show InChI InChI=1S/C19H17Cl2F3N2O/c20-15-3-1-2-14(16(15)21)17(27)26-11-18(4-6-19(23,24)7-5-18)12-8-13(22)10-25-9-12/h1-3,8-10H,4-7,11H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9649308 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R29
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173674 (US9102591, 2,3-dichloro-N-((4,4-difluoro-1-(5-fluo...) Show SMILES Fc1cncc(c1)C1(CNC(=O)c2cccc(Cl)c2Cl)CCC(F)(F)CC1 Show InChI InChI=1S/C19H17Cl2F3N2O/c20-15-3-1-2-14(16(15)21)17(27)26-11-18(4-6-19(23,24)7-5-18)12-8-13(22)10-25-9-12/h1-3,8-10H,4-7,11H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9102591 (2015) BindingDB Entry DOI: 10.7270/Q2028Q92
					More data for this Ligand-Target Pair