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BDBM17383 1,2,4-Triazole Compound, 41::N-(4-chlorophenyl)-5-[(pyridin-4-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-amine

SMILES: Clc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1

InChI Key: InChIKey=JNLUFMFMIAITLU-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17383   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM17383
PNG
(1,2,4-Triazole Compound, 41 | N-(4-chlorophenyl)-5...)
Show SMILES Clc1ccc(Nc2nnc(SCc3ccncc3)[nH]2)cc1
Show InChI InChI=1S/C14H12ClN5S/c15-11-1-3-12(4-2-11)17-13-18-14(20-19-13)21-9-10-5-7-16-8-6-10/h1-8H,9H2,(H2,17,18,19,20)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
2.5n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair