BDBM173848 US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[2-(difluoromethyl)pyrimidin-5-yl]propyl]benzamide::US9102591, (-)2,3-dichloro-N-[3-cyclopropyl-2-[2-(difluoromethyl)pyrimidin-5-yl]propyl]benzamide::US9649308, (-)2,3-dichloro-N-[3-cyclopropyl-2-[2-(difluoromethyl)pyrimidin-5-yl]propyl]benzamide

SMILES: FC(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1

InChI Key: InChIKey=UJBRWGBNEXTWRG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 173848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173848 (US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[2-(...) Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1 Show InChI InChI=1S/C18H17Cl2F2N3O/c19-14-3-1-2-13(15(14)20)18(26)25-7-11(6-10-4-5-10)12-8-23-17(16(21)22)24-9-12/h1-3,8-11,16H,4-7H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	25
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9102591 (2015) BindingDB Entry DOI: 10.7270/Q2028Q92
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173848 (US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[2-(...) Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1 Show InChI InChI=1S/C18H17Cl2F2N3O/c19-14-3-1-2-13(15(14)20)18(26)25-7-11(6-10-4-5-10)12-8-23-17(16(21)22)24-9-12/h1-3,8-11,16H,4-7H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9649308 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R29
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173848 (US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[2-(...) Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1 Show InChI InChI=1S/C18H17Cl2F2N3O/c19-14-3-1-2-13(15(14)20)18(26)25-7-11(6-10-4-5-10)12-8-23-17(16(21)22)24-9-12/h1-3,8-11,16H,4-7H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9649308 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R29
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173848 (US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[2-(...) Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1 Show InChI InChI=1S/C18H17Cl2F2N3O/c19-14-3-1-2-13(15(14)20)18(26)25-7-11(6-10-4-5-10)12-8-23-17(16(21)22)24-9-12/h1-3,8-11,16H,4-7H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
H. Lundbeck A/S US Patent					Assay Description Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...				US Patent US9102591 (2015) BindingDB Entry DOI: 10.7270/Q2028Q92
					More data for this Ligand-Target Pair