null

SMILES: CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1ncnc2[nH]ccc12

InChI Key: InChIKey=JVQOMNPLAVRLAJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 173936   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [861-1152] (Homo sapiens (Human))	BDBM173936 (US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...) Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C19H14ClN5/c1-2-12-3-4-14(20)8-17(12)25-10-13(7-15(25)9-21)18-16-5-6-22-19(16)24-11-23-18/h3-8,10-11H,2H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...				US Patent US9688661 (2017) BindingDB Entry DOI: 10.7270/Q2K35RTP
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [833-1187] (Homo sapiens (Human))	BDBM173936 (US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...) Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C19H14ClN5/c1-2-12-3-4-14(20)8-17(12)25-10-13(7-15(25)9-21)18-16-5-6-22-19(16)24-11-23-18/h3-8,10-11H,2H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...				US Patent US9688661 (2017) BindingDB Entry DOI: 10.7270/Q2K35RTP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM173936 (US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...) Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C#N)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C19H14ClN5/c1-2-12-3-4-14(20)8-17(12)25-10-13(7-15(25)9-21)18-16-5-6-22-19(16)24-11-23-18/h3-8,10-11H,2H2,1H3,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...				US Patent US9688661 (2017) BindingDB Entry DOI: 10.7270/Q2K35RTP
					More data for this Ligand-Target Pair