BDBM176588 US9120761, 2
SMILES: COc1cc(ccc1Nc1ncc(c(CCc2ccccc2CC(N)=O)n1)C(F)(F)F)C1CCNCC1
InChI Key: InChIKey=FJMPEQKEWCBVKU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Focal adhesion kinase (FAK) (Mus musculus (Mouse)) | BDBM176588 (US9120761, 2) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Cancer Therapeutics CRC PTY LTD US Patent | Assay Description A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) S... | US Patent US9120761 (2015) BindingDB Entry DOI: 10.7270/Q22N511J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Focal adhesion kinase (FAK) (Mus musculus (Mouse)) | BDBM176588 (US9120761, 2) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.740 | n/a | n/a | n/a | 7.4 | n/a |
Cancer Therapeutics CRC PTY LTD US Patent | Assay Description In running buffer (0.01 M HEPES pH 7.4, 0.15 M NaCl, 0.005% Surfactant P20, mM MgCl2, and 1% DMSO)N-terminally GST-fused purified FAK enzyme was capt... | US Patent US9120761 (2015) BindingDB Entry DOI: 10.7270/Q22N511J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
modified VEGFR3 cytoplasmic domain (Homo sapiens (Human)) | BDBM176588 (US9120761, 2) | GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.69E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Cancer Therapeutics CRC PTY LTD US Patent | Assay Description Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ... | US Patent US9120761 (2015) BindingDB Entry DOI: 10.7270/Q22N511J | |||||||||||
More data for this Ligand-Target Pair |