BDBM17671 benzimidazole analogue, 50::methyl 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-1H-1,3-benzodiazole-4-carboxylate
SMILES: COC(=O)c1cccc2n(Cc3c(F)cccc3F)c(nc12)-c1c(F)cccc1F
InChI Key: InChIKey=ARZDBTKIMHITPH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM17671 (benzimidazole analogue, 50 | methyl 2-(2,6-difluor...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.58E+5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
NCI-FCRDC | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 50: 4003-4015 (2007) Article DOI: 10.1021/jm060103d BindingDB Entry DOI: 10.7270/Q25M6409 | |||||||||||
More data for this Ligand-Target Pair |