BDBM17679 2-aminobenzimidazole, 4::N-[4-chloro-3-(trifluoromethyl)phenyl]-5-(pyridin-4-yloxy)-1H-1,3-benzodiazol-2-amine

SMILES: FC(F)(F)c1cc(Nc2nc3ccc(Oc4ccncc4)cc3[nH]2)ccc1Cl

InChI Key: InChIKey=NWABOGDQPNUAEX-UHFFFAOYSA-N

Data: 1 KI

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17679   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17679 (2-aminobenzimidazole, 4 | N-[4-chloro-3-(trifluoro...) Show SMILES FC(F)(F)c1cc(Nc2nc3ccc(Oc4ccncc4)cc3[nH]2)ccc1Cl Show InChI InChI=1S/C19H12ClF3N4O/c20-15-3-1-11(9-14(15)19(21,22)23)25-18-26-16-4-2-13(10-17(16)27-18)28-12-5-7-24-8-6-12/h1-10H,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	160	-9.17	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair