BDBM176791 US9675612, 30 7-[(6-Ethoxy-1H-indazol-5-yl)amino]-N, N-dimethyl[1,3]thiazolo[5,4-d]pyrimidine-2-carboxamide

SMILES: CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C

InChI Key: InChIKey=WRSLSMOUHFZACQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176791   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM176791 (US9675612, 30 7-[(6-Ethoxy-1H-indazol-5-yl)amino]-...) Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C Show InChI InChI=1S/C17H17N7O2S/c1-4-26-12-6-10-9(7-20-23-10)5-11(12)21-14-13-15(19-8-18-14)27-16(22-13)17(25)24(2)3/h5-8H,4H2,1-3H3,(H,20,23)(H,18,19,21)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	7.5	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9675612 (2017) BindingDB Entry DOI: 10.7270/Q2RN3612
					More data for this Ligand-Target Pair