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BDBM17691 2-aminobenzimidazole, 16::N-{4-chloro-3-[(4-methylpiperazin-1-yl)methyl]phenyl}-5-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}-1H-1,3-benzodiazol-2-amine

SMILES: CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ccnc6[nH]ccc56)cc4[nH]3)ccc2Cl)CC1

InChI Key: InChIKey=GXVPRRQXIWVLPD-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17691   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17691
PNG
(2-aminobenzimidazole, 16 | N-{4-chloro-3-[(4-methy...)
Show SMILES CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ccnc6[nH]ccc56)cc4[nH]3)ccc2Cl)CC1
Show InChI InChI=1S/C26H26ClN7O/c1-33-10-12-34(13-11-33)16-17-14-18(2-4-21(17)27)30-26-31-22-5-3-19(15-23(22)32-26)35-24-7-9-29-25-20(24)6-8-28-25/h2-9,14-15H,10-13,16H2,1H3,(H,28,29)(H2,30,31,32)
PDB
MMDB

NCI pathway
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PC cid
PC sid
UniChem

Patents

Article
PubMed
3 -11.5n/an/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
More data for this
Ligand-Target Pair