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BDBM176910 US9120749, 276

SMILES: COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(N3CCC(CN(C)C)CC3)c2c1

InChI Key: InChIKey=KBEIMUAZVQXFGN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176910   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))		BDBM176910
PNG
(US9120749, 276)
Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(N3CCC(CN(C)C)CC3)c2c1
Show InChI InChI=1S/C28H32ClN3O3/c1-31(2)16-17-8-10-32(11-9-17)26-21-12-19(20-13-23(29)28(34)25(14-20)35-3)6-7-24(21)30-15-22(26)27(33)18-4-5-18/h6-7,12-15,17-18,34H,4-5,8-11,16H2,1-3H3
PDB

KEGG

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antibodypedia
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.800n/an/an/an/a7.425



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...

US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair