BDBM177285 US9120749, 651
SMILES: N[C@@H]1CCCN(C1)c1ccc(Nc2c(cnc3ccc(cc23)-c2cc(F)c(O)c(Cl)c2)C(=O)C2CC2)cn1
InChI Key: InChIKey=XCIFPBRCAMMOCR-LJQANCHMSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maternal embryonic leucine zipper kinase (MELK) (Homo sapiens (Human)) | BDBM177285 (US9120749, 651) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ONCOTHERAPY SCIENCE, INC. US Patent | Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ... | US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872 | |||||||||||
More data for this Ligand-Target Pair |