BDBM17735 2,6-dimethylphenyl N-(2-{[3,5-dimethoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-N-(2,4-dimethoxyphenyl)carbamate::2-aminopyrimidine carbamate, 34

SMILES: COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1

InChI Key: InChIKey=QQVSOFKHHODIKB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM17735 (2,6-dimethylphenyl N-(2-{[3,5-dimethoxy-4-(4-methy...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 Show InChI InChI=1S/C34H40N6O6/c1-22-9-8-10-23(2)32(22)46-34(41)40(26-12-11-25(42-4)21-27(26)43-5)30-13-14-35-33(37-30)36-24-19-28(44-6)31(29(20-24)45-7)39-17-15-38(3)16-18-39/h8-14,19-21H,15-18H2,1-7H3,(H,35,36,37)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17735 (2,6-dimethylphenyl N-(2-{[3,5-dimethoxy-4-(4-methy...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 Show InChI InChI=1S/C34H40N6O6/c1-22-9-8-10-23(2)32(22)46-34(41)40(26-12-11-25(42-4)21-27(26)43-5)30-13-14-35-33(37-30)36-24-19-28(44-6)31(29(20-24)45-7)39-17-15-38(3)16-18-39/h8-14,19-21H,15-18H2,1-7H3,(H,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM17735 (2,6-dimethylphenyl N-(2-{[3,5-dimethoxy-4-(4-methy...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 Show InChI InChI=1S/C34H40N6O6/c1-22-9-8-10-23(2)32(22)46-34(41)40(26-12-11-25(42-4)21-27(26)43-5)30-13-14-35-33(37-30)36-24-19-28(44-6)31(29(20-24)45-7)39-17-15-38(3)16-18-39/h8-14,19-21H,15-18H2,1-7H3,(H,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM17735 (2,6-dimethylphenyl N-(2-{[3,5-dimethoxy-4-(4-methy...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(N4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 Show InChI InChI=1S/C34H40N6O6/c1-22-9-8-10-23(2)32(22)46-34(41)40(26-12-11-25(42-4)21-27(26)43-5)30-13-14-35-33(37-30)36-24-19-28(44-6)31(29(20-24)45-7)39-17-15-38(3)16-18-39/h8-14,19-21H,15-18H2,1-7H3,(H,35,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair