BDBM17745 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({3-fluoro-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)pyrimidin-4-yl]carbamate::2-aminopyrimidine carbamate, 44

SMILES: COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1

InChI Key: InChIKey=UPXVJAHQYQWZKZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM17745 (2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1 Show InChI InChI=1S/C35H41FN6O5/c1-24-8-6-9-25(2)33(24)47-35(43)42(29-12-11-27(44-4)23-31(29)45-5)32-14-15-37-34(39-32)38-26-10-13-30(28(36)22-26)46-21-7-16-41-19-17-40(3)18-20-41/h6,8-15,22-23H,7,16-21H2,1-5H3,(H,37,38,39)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17745 (2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1 Show InChI InChI=1S/C35H41FN6O5/c1-24-8-6-9-25(2)33(24)47-35(43)42(29-12-11-27(44-4)23-31(29)45-5)32-14-15-37-34(39-32)38-26-10-13-30(28(36)22-26)46-21-7-16-41-19-17-40(3)18-20-41/h6,8-15,22-23H,7,16-21H2,1-5H3,(H,37,38,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM17745 (2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1 Show InChI InChI=1S/C35H41FN6O5/c1-24-8-6-9-25(2)33(24)47-35(43)42(29-12-11-27(44-4)23-31(29)45-5)32-14-15-37-34(39-32)38-26-10-13-30(28(36)22-26)46-21-7-16-41-19-17-40(3)18-20-41/h6,8-15,22-23H,7,16-21H2,1-5H3,(H,37,38,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM17745 (2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...) Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1 Show InChI InChI=1S/C35H41FN6O5/c1-24-8-6-9-25(2)33(24)47-35(43)42(29-12-11-27(44-4)23-31(29)45-5)32-14-15-37-34(39-32)38-26-10-13-30(28(36)22-26)46-21-7-16-41-19-17-40(3)18-20-41/h6,8-15,22-23H,7,16-21H2,1-5H3,(H,37,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 49: 4981-91 (2006) Article DOI: 10.1021/jm060435i BindingDB Entry DOI: 10.7270/Q2SB440C
					More data for this Ligand-Target Pair