null

SMILES: CN1CCc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1

InChI Key: InChIKey=KFVZZFYWUVNRIW-BHVANESWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177847 (US9120791, Example 66 | US9603854, 66) Show SMILES CN1CCc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H42ClN5O4/c1-47-19-17-31-25-35(12-16-41(31)47)51(34-10-13-37(52)14-11-34)45(54)40-27-43(49-18-5-4-8-42(40)49)39-26-33(46)9-15-38(39)44(53)50-28-32-7-3-2-6-30(32)24-36(50)29-48-20-22-55-23-21-48/h2-16,18,25-27,36,52H,17,19-24,28-29H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177847 (US9120791, Example 66 | US9603854, 66) Show SMILES CN1CCc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccccc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H42ClN5O4/c1-47-19-17-31-25-35(12-16-41(31)47)51(34-10-13-37(52)14-11-34)45(54)40-27-43(49-18-5-4-8-42(40)49)39-26-33(46)9-15-38(39)44(53)50-28-32-7-3-2-6-30(32)24-36(50)29-48-20-22-55-23-21-48/h2-16,18,25-27,36,52H,17,19-24,28-29H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair