BDBM17868 (2S)-2-amino-4-(methylsulfanyl)-1-(pyridin-2-yl)butan-1-one::keto-heterocycle inhibitor, 2
SMILES: CSCC[C@H](N)C(=O)c1ccccn1
InChI Key: InChIKey=ARURVSWVWKOIIJ-QMMMGPOBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Methionine Aminopeptidase (Staphylococcus aureus) | BDBM17868 ((2S)-2-amino-4-(methylsulfanyl)-1-(pyridin-2-yl)bu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Morphochem AG | Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c... | J Med Chem 47: 1325-8 (2004) Article DOI: 10.1021/jm034188j BindingDB Entry DOI: 10.7270/Q2GX48TV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |