BDBM179450 US9675616, 7 2-Amino-N-(8-{[(2R)-2-hydroxy-3-{[(1S)-1-phenylethyl]amino}propyl]oxy}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide
SMILES: COc1c(OC[C@H](O)CN[C@@H](C)c2ccccc2)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12
InChI Key: InChIKey=BYDCRJQCYFLXHA-QFBILLFUSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM179450 (US9675616, 7 2-Amino-N-(8-{[(2R)-2-hydroxy-3-{[(1S...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER INTELLECTUAL PROPERTY GMBH US Patent | Assay Description For the assay 50 nL of a 80-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384-well microtiter plate (G... | US Patent US9675616 (2017) BindingDB Entry DOI: 10.7270/Q2H41PKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM179450 (US9675616, 7 2-Amino-N-(8-{[(2R)-2-hydroxy-3-{[(1S...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER INTELLECTUAL PROPERTY GMBH US Patent | Assay Description For the assay 50 mL of a 80-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384-well microtiter plate (G... | US Patent US9675616 (2017) BindingDB Entry DOI: 10.7270/Q2H41PKX | |||||||||||
More data for this Ligand-Target Pair |