BDBM180008 US9676720, Comparative example 4
SMILES: OC(=O)CNc1cccc(CN(Cc2ccc(cc2)-c2ccc(Cl)cc2)S(=O)(=O)c2cccnc2)n1
InChI Key: InChIKey=YDTMHXWCCXZZHQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human)) | BDBM180008 (US9676720, Comparative example 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >10 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
UBE INDUSTRIES, LTD. US Patent | Assay Description Measurement of EP2 receptor binding action was performed in accordance with the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285... | US Patent US9676720 (2017) BindingDB Entry DOI: 10.7270/Q2057D39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM180008 (US9676720, Comparative example 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
UBE Industries, Ltd. Curated by ChEMBL | Assay Description Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins | J Med Chem 61: 6869-6891 (2018) Article DOI: 10.1021/acs.jmedchem.8b00808 | |||||||||||
More data for this Ligand-Target Pair |