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SMILES: O=C(N1CCOCC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1

InChI Key: InChIKey=SABCUTYZLSBOFU-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180257   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM180257
PNG
(US9676721, 78 2-cyano-1-{[4-({3-[(morpholin-4-yl)c...)
Show SMILES O=C(N1CCOCC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:31.34|
Show InChI InChI=1S/C25H24N6O4S/c26-18-29-25(30-21-8-10-27-11-9-21)28-17-19-4-6-22(7-5-19)36(33,34)23-3-1-2-20(16-23)24(32)31-12-14-35-15-13-31/h1-11,16H,12-15,17H2,(H2,27,28,29,30)
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MMDB

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US Patent
n/an/a 1.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...

US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair