BDBM180929 US9133187, I-1

SMILES: Clc1ccc(cc1Cl)[C@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cnco1

InChI Key: InChIKey=ZTXAUJJTZSOBRX-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180929   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180929 (US9133187, I-1) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cnco1 |r| Show InChI InChI=1S/C23H24Cl2N6O3/c24-17-2-1-14(9-18(17)25)21(20-11-26-13-34-20)30-23(32)31-6-3-15-10-27-22(29-19(15)12-31)28-16-4-7-33-8-5-16/h1-2,9-11,13,16,21H,3-8,12H2,(H,30,32)(H,27,28,29)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
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