null

SMILES: Fc1cc(ccc1Cl)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cn[nH]c1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180932 (US9133187, I-7) Show SMILES Fc1cc(ccc1Cl)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1cn[nH]c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair