BDBM180935 US9133187, I-15

SMILES: CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F

InChI Key: InChIKey=VXDYYJPLOFIVKA-QSVWIEALSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180935   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180935 (US9133187, I-15) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C23H28F4N6O/c1-13(2)30-21-29-11-15-7-9-33(12-19(15)31-21)22(34)32-20(18-4-3-8-28-18)14-5-6-16(17(24)10-14)23(25,26)27/h5-6,10-11,13,18,20,28H,3-4,7-9,12H2,1-2H3,(H,32,34)(H,29,30,31)/t18-,20?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair