BDBM181068 (E)-N'-(4-Chlorobenzylidene)-4-(2-oxo-2H-chromen-3-yl)thiazole-2-carbohydrazide (7m)
SMILES: Clc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)cc1
InChI Key: InChIKey=MNZDVVMPMDUIOM-LSHDLFTRSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Probable maltase-glucoamylase 2 (Homo sapiens) | BDBM181068 ((E)-N'-(4-Chlorobenzylidene)-4-(2-oxo-2H-chrom...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL | Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitro phenyl glucopyranoside as substrate preincubated for 10 mins followed by substrate add... | Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL12 (Saccharomyces cerevisiae) | BDBM181068 ((E)-N'-(4-Chlorobenzylidene)-4-(2-oxo-2H-chrom...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Jishou University | Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u... | Bioorg Chem 65: 167-74 (2016) Article DOI: 10.1016/j.bioorg.2016.03.001 BindingDB Entry DOI: 10.7270/Q2445K8R | |||||||||||
More data for this Ligand-Target Pair |