BDBM181133 US10093658, Compound Allopurinol::US10752613, Compound Allopurinol::US9138393, Allopurinol::US9144538, Allopurinol
SMILES: Oc1ncnc2[nH]ncc12
InChI Key: InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N
Data: 11 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company US Patent | Assay Description A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ... | US Patent US9138393 (2015) BindingDB Entry DOI: 10.7270/Q2GF0S8J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company US Patent | Assay Description Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ... | US Patent US9144538 (2015) BindingDB Entry DOI: 10.7270/Q22806DV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US10093658 (2018) BindingDB Entry DOI: 10.7270/Q2NZ89PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:... | US Patent US10093658 (2018) BindingDB Entry DOI: 10.7270/Q2NZ89PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US10752613 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINA PHARMACEUTICAL UNIVERSITY US Patent | Assay Description 11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m... | US Patent US11021454 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US11020397 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:... | US Patent US11020397 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US11020397 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:... | US Patent US11020397 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Homo sapiens (Human)) | BDBM181133 (US10093658, Compound Allopurinol | US10752613, Com...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:... | US Patent US10752613 (2020) | |||||||||||
More data for this Ligand-Target Pair |