BindingDB PrimarySearch

BDBM18133 2-aminoacetic acid::CHEMBL773::Glycine::[14C]Glycine

SMILES: NCC(O)=O

InChI Key: InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N

Data: 4 KI 5 IC50 1 EC50

PDB links: 70 PDB IDs match this monomer. 2691 PDB IDs contain this monomer as substructures. 13 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 18133
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serine racemase (Homo sapiens (Human))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	3.66E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Binding affinity to serine recemase (unknown origin)				Bioorg Med Chem Lett 24: 3732-5 (2014) Article DOI: 10.1016/j.bmcl.2014.07.003 BindingDB Entry DOI: 10.7270/Q2PR7XNR
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair
Proton-coupled amino acid transporter 1 (Homo sapiens (Human))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	DrugBank Article PubMed	5.10E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting				Bioorg Med Chem 19: 6409-18 (2011) Checked by Author Article DOI: 10.1016/j.bmc.2011.08.058 BindingDB Entry DOI: 10.7270/Q2NZ882D
					More data for this Ligand-Target Pair
Glycine receptor subunit alpha-1 (Homo sapiens (Human))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	9.55E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay				J Med Chem 50: 4616-29 (2007) Article DOI: 10.1021/jm070574f BindingDB Entry DOI: 10.7270/Q2J67HRC
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
GABA transporter (Mus musculus)	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.35E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells				Eur J Med Chem 46: 1483-98 (2011) Article DOI: 10.1016/j.ejmech.2011.01.042 BindingDB Entry DOI: 10.7270/Q2F76CWJ
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair
Glycine transporter 1 (Homo sapiens (Human))	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	DrugBank Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake				Bioorg Med Chem Lett 24: 1067-70 (2014) Article DOI: 10.1016/j.bmcl.2014.01.013 BindingDB Entry DOI: 10.7270/Q2K64KK4
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor				Bioorg Med Chem Lett 9: 1409-14 (1999) BindingDB Entry DOI: 10.7270/Q2W0954Z
Institut de Recherches Servier Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration of the compound required to inhibit [3H]-strychnine binding to N-methyl-D-aspartate glutamate receptor 1				J Med Chem 35: 233-41 (1992) BindingDB Entry DOI: 10.7270/Q26W9911
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA transporter (Mus musculus)	BDBM18133 (2-aminoacetic acid \| CHEMBL773 \| Glycine \| [14C]Gl...) Show SMILES NCC(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.24E+6	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Munich Curated by ChEMBL					Assay Description Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells				Eur J Med Chem 46: 1483-98 (2011) Article DOI: 10.1016/j.ejmech.2011.01.042 BindingDB Entry DOI: 10.7270/Q2F76CWJ
Ludwig-Maximilians-University Munich Curated by ChEMBL					More data for this Ligand-Target Pair