BDBM181544 US9139577, 4.050::US9708274, 4.050

SMILES: CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1

InChI Key: InChIKey=VFMKAEVQTZGTPR-QRWMCTBCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181544 (US9139577, 4.050 | US9708274, 4.050) Show SMILES CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1 |r| Show InChI InChI=1S/C26H32FN5O3S/c1-5-17(3)30-26(33)18(4)35-23-13-19(27)8-9-21(23)31-25-24-16(2)12-20(14-22(24)28-15-29-25)32-36(34)10-6-7-11-36/h8-9,12-15,17-18H,5-7,10-11H2,1-4H3,(H,30,33)(H,28,29,31)/t17?,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181544 (US9139577, 4.050 | US9708274, 4.050) Show SMILES CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1 |r| Show InChI InChI=1S/C26H32FN5O3S/c1-5-17(3)30-26(33)18(4)35-23-13-19(27)8-9-21(23)31-25-24-16(2)12-20(14-22(24)28-15-29-25)32-36(34)10-6-7-11-36/h8-9,12-15,17-18H,5-7,10-11H2,1-4H3,(H,30,33)(H,28,29,31)/t17?,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9139577 (2015) BindingDB Entry DOI: 10.7270/Q2K64GT1
					More data for this Ligand-Target Pair