BDBM181631 US9139577, 4.137::US9708274, 4.137

SMILES: C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N

InChI Key: InChIKey=MMCQEPRCXRALFW-UONOGXRCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181631   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181631 (US9139577, 4.137 | US9708274, 4.137) Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181631 (US9139577, 4.137 | US9708274, 4.137) Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N |r| Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9139577 (2015) BindingDB Entry DOI: 10.7270/Q2K64GT1
					More data for this Ligand-Target Pair