BDBM181759 US9139585, 35B

SMILES: Cc1cc(ncc1[C@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)-n1cnnn1

InChI Key: InChIKey=SCDIGACNDVULSQ-FCHUYYIVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM181759 (US9139585, 35B) Show SMILES Cc1cc(ncc1[C@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)-n1cnnn1 |r| Show InChI InChI=1S/C24H29N7O4/c1-15-9-23(31-14-26-27-28-31)25-10-19(15)22(33)12-30-7-5-29(6-8-30)11-21(32)17-3-4-18-20(16(17)2)13-35-24(18)34/h3-4,9-10,14,21-22,32-33H,5-8,11-13H2,1-2H3/t21-,22+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.5	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9139585 (2015) BindingDB Entry DOI: 10.7270/Q29P30F8
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