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BDBM182242 US9145391, 14

SMILES: CC([C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1

InChI Key: InChIKey=VNZOMDYNOUYNSJ-ZNUUHSPMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182242   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182242
PNG
(US9145391, 14)
Show SMILES CC([C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |r,wU:5.8,wD:2.1,(-1.33,3.08,;,2.31,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,;,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,-3.85,;1.33,-4.62,;1.33,-6.16,;2.67,-6.93,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.85,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.31,;-4,-1.54,;-6.67,-1.54,;-5.33,-.77,;-1.33,-4.62,)|
Show InChI InChI=1S/C26H27F3N4O2/c1-15-11-22(32-24(12-15)33-23-13-20(9-10-30-23)26(27,28)29)19-7-8-21(31-14-19)16(2)17-3-5-18(6-4-17)25(34)35/h7-14,16-18H,3-6H2,1-2H3,(H,34,35)(H,30,32,33)/t16?,17-,18-
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Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair