BDBM182462 US9145392, 163
SMILES: CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)-c1ccc(F)c(C)c1
InChI Key: InChIKey=NUPWMMJWFAYJED-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM182462 (US9145392, 163) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Merck Patent GmbH US Patent | Assay Description A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv... | US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human)) | BDBM182462 (US9145392, 163) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Patent GmbH US Patent | Assay Description P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo... | US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2 | |||||||||||
More data for this Ligand-Target Pair |