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SMILES: CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N

InChI Key: InChIKey=JUWXCOQVEVSURH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182705   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM182705
PNG
(US9145402, 11)
Show SMILES CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N
Show InChI InChI=1S/C18H21FN6O2/c1-21-17-13(9-20)10-22-18(24-17)23-15-8-14(19)12(7-16(15)26-2)11-25-3-5-27-6-4-25/h7-8,10H,3-6,11H2,1-2H3,(H2,21,22,23,24)
PDB

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Similars
US Patent
 27n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...

US Patent US9145402 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FQ3
More data for this
Ligand-Target Pair