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SMILES: CNc1nc(Nc2cc(C)c(cc2OC)C#N)ncc1C(F)(F)F

InChI Key: InChIKey=ZEMTWSFENJACPQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182707   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM182707
PNG
(US9145402, 13)
Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C15H14F3N5O/c1-8-4-11(12(24-3)5-9(8)6-19)22-14-21-7-10(15(16,17)18)13(20-2)23-14/h4-5,7H,1-3H3,(H2,20,21,22,23)
PDB

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Similars
US Patent
 12n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...

US Patent US9145402 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FQ3
More data for this
Ligand-Target Pair