BDBM182724 US9145402, 31

SMILES: CNc1nc(Nc2cc(F)c(cc2OC)N2CCOCC2=O)ncc1C(F)(F)F

InChI Key: InChIKey=QXVMXBPPRRXMMZ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182724 (US9145402, 31) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)N2CCOCC2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H17F4N5O3/c1-22-15-9(17(19,20)21)7-23-16(25-15)24-11-5-10(18)12(6-13(11)28-2)26-3-4-29-8-14(26)27/h5-7H,3-4,8H2,1-2H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair