BDBM182726 US9145402, 33

SMILES: CNc1nc(Nc2cc(F)c(cc2OC)C2COC2)ncc1C(F)(F)F

InChI Key: InChIKey=DLNHJRGDYSWBNT-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182726 (US9145402, 33) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)C2COC2)ncc1C(F)(F)F Show InChI InChI=1S/C16H16F4N4O2/c1-21-14-10(16(18,19)20)5-22-15(24-14)23-12-4-11(17)9(3-13(12)25-2)8-6-26-7-8/h3-5,8H,6-7H2,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair