BDBM182728 US9145402, 35

SMILES: CCS(=O)(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1C

InChI Key: InChIKey=MRTUCFUNQIQZLX-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182728   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182728 (US9145402, 35) Show SMILES CCS(=O)(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1C Show InChI InChI=1S/C16H19F3N4O3S/c1-5-27(24,25)13-7-12(26-4)11(6-9(13)2)22-15-21-8-10(16(17,18)19)14(20-3)23-15/h6-8H,5H2,1-4H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair