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SMILES: N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C(F)F)n1

InChI Key: InChIKey=ZHIVHAAQBWONFQ-WCQYABFASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182770   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182770
PNG
(US9145414, 26)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C(F)F)n1 |r|
Show InChI InChI=1S/C19H22F2N8O/c20-18(21)29-9-8-10-12(6-3-7-14(10)29)24-17-15(16(23)30)27-28-19(26-17)25-13-5-2-1-4-11(13)22/h3,6-9,11,13,18H,1-2,4-5,22H2,(H2,23,30)(H2,24,25,26,28)/t11-,13+/m0/s1
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Similars
US Patent
n/an/a 0.220n/an/an/an/a7.525



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...

US Patent US9145414 (2015)


BindingDB Entry DOI: 10.7270/Q2513X18
More data for this
Ligand-Target Pair