new BindingDB logo
myBDB logout

BDBM182810 US9145414, 258

SMILES: COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1

InChI Key: InChIKey=VIEQVUDFRPJJDS-KUWVVDADNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182810   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM182810
PNG
(US9145414, 258)
Show SMILES COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1 |r|
Show InChI InChI=1/C23H27N9O2/c1-13(18(24)12-34-3)26-23-28-22(20(21(25)33)29-30-23)27-16-9-15-11-32(2)31-19(15)17(10-16)14-7-5-4-6-8-14/h4-11,13,18H,12,24H2,1-3H3,(H2,25,33)(H2,26,27,28,30)/t13-,18+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/a7.525



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...


US Patent US9145414 (2015)


BindingDB Entry DOI: 10.7270/Q2513X18
More data for this
Ligand-Target Pair