null
SMILES: CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1
InChI Key: InChIKey=VGGMTOYKEDKFLN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182847 (US9149492, K-604) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM182847 (US9149492, K-604) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182847 (US9149492, K-604) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste... | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182847 (US9149492, K-604) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of human ACAT1 | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM182847 (US9149492, K-604) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of human ACAT2 | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair |