BDBM18354 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine-3,4,5-triol::N-Propyl-DNJ
SMILES: CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI Key: InChIKey=DUKKBXHYYSHSAI-BZNPZCIMSA-N
Data: 2 IC50
PDB links: 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
alpha-Glucosidase (alpha-Glu) (Homo sapiens (Human)) | BDBM18354 ((2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | 4.5 | 37 |
Hokuriku University | Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... | Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18354 ((2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
Hokuriku University | Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... | Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B | |||||||||||
More data for this Ligand-Target Pair |