BDBM18359 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperidine-3,4,5-triol::CHEMBL503021::alpha-1-C-Methyl-DNJ

SMILES: C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI Key: InChIKey=ZEWFPWKROPWRKE-XUUWZHRGSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18359   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18359 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperid...) Show SMILES C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+5	n/a	n/a	n/a	n/a	5.5	37
Hokuriku University					Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...				Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B
					More data for this Ligand-Target Pair
alpha-Glucosidase (alpha-Glu) (Homo sapiens (Human))	BDBM18359 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperid...) Show SMILES C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	4.5	37
Hokuriku University					Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...				Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B
					More data for this Ligand-Target Pair
Acidic alpha-glucosidase (Rattus norvegicus)	BDBM18359 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperid...) Show SMILES C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test				J Nat Prod 65: 1875-81 (2002) Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4
					More data for this Ligand-Target Pair
Acidic alpha-glucosidase (Rattus norvegicus)	BDBM18359 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperid...) Show SMILES C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test				J Nat Prod 65: 1875-81 (2002) Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4
					More data for this Ligand-Target Pair
β-galactosidase (Bos taurus (Bovine))	BDBM18359 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperid...) Show SMILES C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of bovine liver beta-galactosidase assessed as p-nitrophenol release after 30 mins by spectrophotometry				J Nat Prod 65: 1875-81 (2002) Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4
					More data for this Ligand-Target Pair