BDBM18364 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidine-3,4,5-triol::CN-DNJ::US9181184, 32::alpha-1-C-Nonyl-DNJ
SMILES: CCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InChI Key: InChIKey=PMSTUSHNMMAWCI-UXXRCYHCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18364 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 200 | -9.50 | 270 | n/a | n/a | n/a | n/a | 5.5 | 37 |
Hokuriku University | Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... | Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-glucosidase (Gaa) (Mus musculus (Mouse)) | BDBM18364 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | n/a | n/a | 7.00E+3 | n/a | n/a | 4.0 | n/a |
Amicus Therapeutics, Inc. US Patent | Assay Description Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho... | US Patent US9181184 (2015) BindingDB Entry DOI: 10.7270/Q2T43RWB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (alpha-Glu) (Homo sapiens (Human)) | BDBM18364 ((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | 4.5 | 37 |
Hokuriku University | Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... | Bioorg Med Chem 14: 7736-44 (2006) Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B | |||||||||||
More data for this Ligand-Target Pair |