BDBM18433 4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)quinolin-6-yl]cyclohexane-1-carboxamide::Aminoquinoline compound, 18
SMILES: CC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCC(C)CC1
InChI Key: InChIKey=LPXVCPVAKUZWGD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18433 (4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)qui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 120 | -9.31 | 268 | n/a | n/a | n/a | n/a | 5.9 | 21 |
NIH | Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss... | Proc Natl Acad Sci U S A 104: 13192-7 (2007) Article DOI: 10.1073/pnas.0705637104 BindingDB Entry DOI: 10.7270/Q2V1232M | |||||||||||
More data for this Ligand-Target Pair |