BDBM185151 4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid::OSI-027
SMILES: COc1cccc2=C\C(N=c12)=c1\nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12
InChI Key: InChIKey=CDNMDRUIGNHEMR-VKAVYKQESA-N
Data: 1 Kd
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Ferrochelatase R115L (FECH) (Homo sapiens (Human)) | BDBM185151 (4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-im...) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a |
Technical University of Munich | Assay Description Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30... | ACS Chem Biol 11: 1245-54 (2016) Article DOI: 10.1021/acschembio.5b01063 BindingDB Entry DOI: 10.7270/Q2FB51R8 | |||||||||||
More data for this Ligand-Target Pair |