BDBM18526 6-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one::6-amino-4-trifluoromethylquinolin-2(1H)-one, 3
SMILES: Nc1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F
InChI Key: InChIKey=LMXZMEMPGRLDIG-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen Receptor (Homo sapiens (Human)) | BDBM18526 (6-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | >-7.09 | 26 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Ligand Pharmaceuticals Inc. | Assay Description The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece... | J Med Chem 49: 6143-6 (2006) Article DOI: 10.1021/jm060792t BindingDB Entry DOI: 10.7270/Q26971VV | |||||||||||
More data for this Ligand-Target Pair |