BDBM18540 7-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one::amino-2-quinolinone, 8
SMILES: Nc1ccc2c(cc(=O)[nH]c2c1)C(F)(F)F
InChI Key: InChIKey=JBCMJMNWLFZJNV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen Receptor (Homo sapiens (Human)) | BDBM18540 (7-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 407 | -9.06 | 28 | n/a | 1.30E+3 | n/a | n/a | 7.4 | 37 |
Ligand Pharmaceuticals Inc. | Assay Description The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece... | Bioorg Med Chem Lett 17: 1523-6 (2007) Article DOI: 10.1016/j.bmcl.2007.01.007 BindingDB Entry DOI: 10.7270/Q22J6950 | |||||||||||
More data for this Ligand-Target Pair |