null

SMILES: Cc1nc(OCC2(F)CCOCC2)sc1S(=O)(=O)NC(=O)c1ccc(cc1Oc1cccc2[nH]ncc12)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=GOYLXRTUWKDPDY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185635   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2/Glutathione S-transferase P (Homo sapiens (Human))	BDBM185635 (US9156856, 48 | US9493431, 48) Show SMILES Cc1nc(OCC2(F)CCOCC2)sc1S(=O)(=O)NC(=O)c1ccc(cc1Oc1cccc2[nH]ncc12)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:47| Show InChI InChI=1S/C43H48ClFN6O6S2/c1-28-40(58-41(47-28)56-27-43(45)15-21-55-22-16-43)59(53,54)49-39(52)33-12-11-32(23-38(33)57-37-6-4-5-36-35(37)25-46-48-36)51-19-17-50(18-20-51)26-30-13-14-42(2,3)24-34(30)29-7-9-31(44)10-8-29/h4-12,23,25H,13-22,24,26-27H2,1-3H3,(H,46,48)(H,49,52)	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.64	-12.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9493431 (2016) BindingDB Entry DOI: 10.7270/Q2RB73HH
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM185635 (US9156856, 48 | US9493431, 48) Show SMILES Cc1nc(OCC2(F)CCOCC2)sc1S(=O)(=O)NC(=O)c1ccc(cc1Oc1cccc2[nH]ncc12)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:47| Show InChI InChI=1S/C43H48ClFN6O6S2/c1-28-40(58-41(47-28)56-27-43(45)15-21-55-22-16-43)59(53,54)49-39(52)33-12-11-32(23-38(33)57-37-6-4-5-36-35(37)25-46-48-36)51-19-17-50(18-20-51)26-30-13-14-42(2,3)24-34(30)29-7-9-31(44)10-8-29/h4-12,23,25H,13-22,24,26-27H2,1-3H3,(H,46,48)(H,49,52)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.64	-12.0	n/a	n/a	n/a	n/a	n/a	n/a	25
AbbVie Inc. US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 μM (2× starting concentration; 10% DMSO) and 10 μ...				US Patent US9156856 (2015) BindingDB Entry DOI: 10.7270/Q2125RFF
					More data for this Ligand-Target Pair